Double-stranded RNA (dsRNA) is RNA with two complementary strands found in cells. It is similar to DNA but with the replacement of thymine by uracil and the adding of one oxygen atom. [1]

Double-stranded RNA (dsRNA) is associated with most viral infections — it either constitutes the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral replication.

Nov 23, 2021 · Double-stranded RNA (dsRNA) is associated with most viral infections — it either constitutes the viral genome (in the case of dsRNA viruses) or is generated in host cells during …

Double-stranded RNA (dsRNA) is synthesized during the course of infection by RNA viruses as a byproduct of replication and transcription and acts as a potent trigger of the host innate …

Jun 21, 2025 · Double-stranded RNA shares similarities with DNA but has defining characteristics. Like DNA, dsRNA forms a right-handed double helix, but it adopts a configuration known as …

Dec 19, 2023 · Recognition of foreign and endogenous dsRNAs is complicated by the sequence-independent binding of dsRNA-binding proteins. Cottrell, Andrews, and Bass review the …

Feb 2, 2023 · In an uninfected cell, dsRNA rarely circulates, but upon viral infection, this nucleic acid can build up. The foreign dsRNA activates the innate immune response machinery of the …

Apr 9, 2025 · Excess double-stranded RNA (dsRNA) is present in the cytoplasm of human cells, usually following viral infections. Recognition of dsRNAs activates innate immune pathways, …

The dsRNA segments underwent enzymatic processing that enabled them to attach to molecules of messenger RNA (mRNA) possessing complementary nucleotide sequences.

Apr 17, 2024 · However, a significant challenge associated with IVT is the residual double-stranded RNA (dsRNA) produced as a by-product. This dsRNA can activate innate immune …