The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in …

MYC has two paralogues: MYCL and MYCN. The initially held view was that MYC is ubiquitously involved in human cancers (both haematological and solid), whereas L-MYC is associated with …

Nov 14, 2025 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell …

Feb 19, 2025 · This Review provides an overview of the various strategies to inhibit MYC, focusing on the most recently described inhibitors and those that have reached clinical trials.

Aug 10, 2022 · As an oncogenic driver, MYC amplifies global transcription by driving pause release and the early transcription, especially of highly expressed genes. It stimulates …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers …

A family of genes that makes proteins involved in many cell functions, including cell growth, cell maturation, and cell death. Genetic changes in the DNA sequence of the MYC genes have …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, …

Aug 9, 2021 · MYC (mostly referred to as c-Myc) is a super-transcription factor encoded by the MYC gene located at chromosome 8 q24.21 [1]. The MYC oncoproteins (C-myc, N-myc, and L …

Oct 24, 2023 · MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression. MYC levels are tightly regulated, and deregulation of MYC has been …