In general, the more vector particles that need to be injected into the brain to achieve transduction of a particular neural cell type, the greater the chance of virus toxicity. Figure 2 ...

Retroviral vectors that are both non-replicating and non-integrating represent a novel and attractive tool that has potential advantages for gene delivery therapy, immunotherapy, and vaccinology.

Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

CAPE TOWN - Health Minister Aaron Motsoaledi says plans to get another 1.1 million people on anti-retroviral (ARV) treatment before the end of the year are not under threat since the withdrawal of ...

More recently, some groups have published concepts to reduce retro-transduction in LV manufacturing and the associated adverse effects on process performance and vector quality. In the following, ...