Controlling the topology and structure of entangled molecular strands is a key challenge in molecular engineering, particularly when attempting to ...

Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared ...

and proteins essential to normal biological function. The procedures presented in this paper allow structure determination at atomic resolution without ever removing the proteins from their membrane ...

Credit: Photo realized Courtesy of DIFFERENT- Restaurant in the Darkness. Source IPC PAS, Grzegorz Krzyzewski Researchers have uncovered the 3D structure of RBP3, a key protein in vision, revealing ...