Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of cysteine residues in GSDMD oligomerization. We show that GSDMD preassembles at the ...

There are 11 human cysteine cathepsins, which primarily function as endopeptidases within endolysosomal compartments. Specific cysteine cathepsins have extracellular functions, for example ...

Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 34141, ...

‡ Materials Science Centre, School of Materials and the Northwest Composites Centre, School of Materials, University of Manchester, Manchester M13 9PL, United Kingdom § College of Engineering, ...

MbnBC catalyzes a four-electron oxidation of a cysteine residue in its precursor-peptide substrate, MbnA, to an oxazolone ring and an adjacent thioamide group. Initial studies of MbnBC indicated the ...

Edited by Mark H. Thiemens, University of California, San Diego, La Jolla, CA, and approved December 22, 2014 (received for review September 28, 2014) ...