We show that hepatic lipid content is similar in ob/ob and ob/ob–p55/p75-null mice (Table 1). Moreover, serum transaminase levels are also not significantly different between ob/ob mice with or ...

Halofuginone can regulate appetite and energy metabolism by increasing the levels of growth differentiation factor 15 (GDF15) ...

Specifically, AgRP neurons, which are located in the hypothalamic arcuate nucleus (ARC) and are hyperactive in Lep ob/ob mice and other rodent models of T2D. To investigate whether chronic AgRP neuron ...

Methods: Study 1: ob/ob mice (Ob-CT) were treated with either prebiotic (Ob-Pre) or non-prebiotic carbohydrates as control (Ob-Cell). Study 2: Ob-CT and Ob-Pre mice were treated with GLP-2 antagonist ...