Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

The cGAS/STING pathway triggers inflammation upon diverse cellular stresses such as infection, cellular damage, aging, and diseases. STING also triggers noncanonical autophagy, involving LC3 ...

and the PI3K‐AKT pathway. Expansion of the autophagosome requires the activity of a ubiquitin‐like conjugation system that lipidated LC3 to the autophagosomal membrane. Autophagy receptors bind LC3 to ...

Mutations in autophagy-related genes have been linked to numerous human diseases, shedding light on new therapeutic targets in the autophagy pathway ... family proteins (LC3 and GABARAP ...

In a process called autophagy ... Understanding how these pathways interact is the first step in preventing lysosomal damage-associated diseases. The article, "LC3 lipidation is essential for ...

Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder.