By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions with autophagy, a key degradation pathway for neuronal cell homeostasis ... with the autophagic machinery via its ...

Our original characterization of the TRGL mouse of varying ages, where low expression of the tgLC3 construct, produces only a very small increment of total LC3, resulting in no discernable functional ...

Confocal images from the cranial-dorsal portion of the striatum (3 images at 120x/section) were collected and representative images for each eGFP-LC3 (green), mRFP- LC3 ... several marker proteins in ...

Acacetin treatment induces a dose-dependent upregulation of autophagy markers, including LC3-II, Beclin-1, and p62, indicating enhanced autophagic activity. This protective effect is attributed to ...

(2) Autophagy Modulation: Certain EOs activate autophagy via the p53 signaling pathway, leading to the upregulation of hepatic LC3-Ⅱ, which facilitates the clearance of necrotic cells. Conversely, ...

Results Rapamycin affected the mTOR signalling pathway in mouse knee joints as indicated by the inhibition of ribosomal protein S6 phosphorylation, a target of mTOR and activation of LC3, a main ...

To investigate whether Liraglutide had a neuroprotective after cardiac arrest and return of spontaneous circulation (CA/ROSC) and explore its potential mechanisms. Adopting an 8-min asphyxial cardiac ...

Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, ...

Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao 266003, P. R. China Qingdao Key Laboratory of Thyroid, Diseases, Medical Research Center, Qingdao 266555, ...