Ultraviolet Absorption Spectra of Nitrogenous Heterocycles. VII. The Effect of Hydroxy Substitutions on the Ultraviolet Absorption of the Series: Hypoxanthine, Xanthine and Uric Acid1 | Journal of the ...

Although the formation of urinary xanthine stones has been anticipated as a possible complication of allopurinol therapy, to date this occurrence has not been documented in the clinical use . . .

Lesch–Nyhan disease (LND) is an X-linked genetic disorder caused by mutations of the hypoxanthine guanine phosphoribosyltransferase (HPRT) purine biosynthesis gene and characterized by aberrant pur ...

In patients with SCD, urinary levels of 8-aminoguanosine and 8-aminoguanine are reduced by ≈60% relative to healthy controls, and this reduction is associated with increased downstream metabolites of ...

Allopurinol has been used for the treatment of gout for the last 40 years, but it is only in the last 15 years that there has been a gathering realisation of its potential benefits in cardiovascular ...

Over 90% of hypoxanthine is recycled as inosine monophosphate (IMP) in the salvage pathway, which plays a crucial role in maintaining energy production.

However, if hypoxanthine was supplemented after the pre-incubation period, the effect of pre-incubation was reversed, and the leukemia cells were again significantly resistant to both 6-MP (Figures 4F ...

What is Lesch-Nyhan syndrome? Read on to learn about this rare X-linked metabolic condition, including its causes, symptoms, and treatment options.

Hypoxanthine plasma levels are an effective, minimally invasive biomarker for diagnosing metabolic dysfunction-related steatohepatitis.

Hypoxanthine is a host-microbial co-metabolite that can be affected by both microbial and host metabolism. Thus, microbiota-derived purines (especially hypoxanthine) appear to represent vital ...

In summary, despite hypoxanthine uptake is the gold standard method for testing in vitro antimalarial activity, our results confirm FCA as a better method to assess stage-specific antimalarial ...