Cancer cells often form the glycocalyx with high levels of cell-surface mucins, which are thought to help protect the cancer cell from immune cell attack. However, a physical understanding of this ...

and reduced tumor growth in breast cancer mouse models. Mucinases clear the glycoprotein branches within the glycocalyx forest, reversing mucin’s multifaceted physical and immunological functions.

By understanding the role of the glycocalyx, scientists may discover better ways to get medicines into the brain, offering hope for conditions ranging from multiple sclerosis to brain cancer.

By understanding the role of the glycocalyx, scientists may discover better ways to get medicines into the brain, offering hope for conditions ranging from multiple sclerosis to brain cancer.

A recent study published in the journal Nature showed that the dysregulation of the brain endothelial glycocalyx layer impairs the blood-brain barrier (BBB) in disease and aging. The BBB forms a ...

It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.

This protective sheath, called the glycocalyx, consists of sugar-rich proteins (glycoproteins). As the first contact to the environment, it determines how cells adhere to surfaces, move and sense ...

One of the ways that cancer cells hide from the body’s immune system is by forming a thin surface barrier called the glycocalyx. In a new study, researchers examined the material properties of ...