Genetic variants in the folic acid metabolic pathway Genetic variants in the folic acid metabolic pathway genes, including MTHFR and RFC, have been found to increase the risk of breast cancer by ...

We report that the pentose phosphate pathway and mitochondrial serine/glycine/folate metabolic signaling, 2 NADPH-generating pathways in the cytosol and mitochondria, respectively, are induced by ...

By limiting folate in animal models, the researchers saw a decrease in processes related to growth and building new cells, but enhanced metabolic flexibility, which Polymenis said could lead to ...

Fig. 2 Sevoflurane anesthesia affected the myelination-related physiological process and signaling pathway in macaque prefrontal cortex. Fig. 3 Folic acid mitigated the damage of the myelin sheath and ...

Methyl groups are one of these chemical modifications, and folate and other associated nutrients are directly involved in the metabolic pathway leading to DNA methylation. “Understanding this ...

As if folate didn't have enough to do, it is critical for dismembering homocysteine, an amino acid produced in the course of protein metabolism. In high concentrations, homocysteine damages the ...

Folic acid deficiency is common due to diet, impaired folate metabolism, and poor nutrient uptake as a result of medications or bariatric surgery. "As much as we've been trying to get the word out ...

uses a unique metabolic pathway, one that normal-growing adult cells rarely use in order to obtain and generate nutrients. This pathway, which requires an enzyme called ornithine aminotransferase ...

Furthermore, specific folate species within the FOCM pathway were associated with both inflammation ... addressing the research question of folate and folate-mediated one-carbon metabolism biomarkers ...