Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory lung disease. Studies have shown that ...

By Sonia Fernandez, UC Santa Barbara Hormone levels fluctuate like the tides, ebbing and flowing according to carefully orchestrated cycles. These hormones not only influence the body, but can cross ...

How your perfume might be disrupting your hormones by mimicking estrogen altering stress response and interfering with ...

Pathway gene sets were identified that were recurrently ... receptors on cancer cells to drive growth factor medicated proliferation independent of estrogen signaling. We find that treatment ...

By blocking estrogen and progesterone on cancer cells ... PR itself or by disrupting its interaction with other signaling pathway may be a new therapeutic opportunity. HER2 Status and ER+/PR+ ...

Further analysis of estrogen deficiency-associated proteins ... of inhibition and activation across IPA-defined canonical signaling pathways and physiological functional analysis, which were ...

Estrogen inhibition pathways include the nuclear factor kappa B (NF-κB) and ER-substance P signaling pathways. Estrogen activation pathways include the phosphatidylinositol 3-kinase (PI3K ...

including genes modulating the estrogen signaling pathway. The latter genes were previously reported to be involved in endocrine resistance, mutually exclusive to ESR1 mutations. Recent findings have ...

This pathway, called the anticipatory Unfolded ... which are therapeutically used to block estrogen signaling in breast cancer," he said. Even though it binds to the same receptor that estrogen ...

2006). More recently, it was reported that dysregulation of Notch signaling pathway was involved in endocrine resistance and combined Notch with estrogen signaling inhibition had showed synergistic ...