The authors confirm that telomeres in telomerase-positive cells terminate with 5'-ATC in a Pot1-dependent manner, and demonstrate that this principle holds true in telomerase-negative ALT cells as ...

Sae2, a cellular protein, coordinates with MRX to stimulate endonuclease and exonuclease activities to initiate DNA end resection. DNA end resection is a two-step process for repairing DSBs.

This is carried out by a dedicated DNA polymerase gamma, with 5’–3’ polymerase and 3’–5’ proofreading/ exonuclease activity. Perturbations to either property can have pathological consequences.

Herein, we have developed a dual amplification strategy for ultrasensitive detection of DNA combining exonuclease III (Exo III)-assisted reaction and DNAzyme motor. DNA probes are carefully designed; ...

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Here, we developed a rapid and efficient DNA-assembling method for routine laboratory work. We discovered that the cleavage speed of T5 exonuclease is approximately 3 nt/min at 0°C and hence developed ...

and an exonuclease called DEDDh to form a trimmer-integrase that catalyzes coordinated DNA capture, trimming, and integration of viral sequences into bacterial DNA. While Tuck’s research ...

The Family DNA polymerases include Tth and Tma DNA polymerase alongside Taq and have 5′-3′ exonuclease activity, but normally lack 3′-5′. In the absence of the 3′-5′ exonuclease ...

Mutations in the TREX1 3’ → 5’ exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway ...

A mediator of this occurrence is mitochondrial genome maintenance exonuclease 1 (MGME1) which can cut both ssDNA and DNA flap substrates. Further studies determining the roles of both MGME1 and ...