Learn more about eLife assessments Cre-loxP technology, a cornerstone in fate mapping and ... (C) Crossing with R26-tdT mice, R26-RSR-Cre exhibits leakiness in E13.5 embryos. Scale bars, yellow 1mm.

Conversely, we next generated FBXW7 fat-conditional knockout mice (FBXW7-FKO mice) by crossing FBXW7-LoxP mice with Adiponectin-Cre mice (Appendix Fig. S6A). We confirmed efficient and specific ...

We show that CCL21-expressing mTECs arise early during embryonic development in mice. By Cre-loxP-mediated fate-mapping analysis, we demonstrate that a vast majority of self-antigen-displaying mTEC ...

A new editorial paper has been published in Oncoscience, titled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this editorial, researchers Piotr Czarnota ...

"One limitation [of Cre-LoxP], the focus of this editorial, is the potential loss of fidelity of Cre recombinase expression especially in the context of modeling cancer in mice." In this new editorial ...

In this new editorial, researchers Piotr Czarnota and Jaroslaw Cisowski from Jagiellonian University discuss Cre-LoxP - a widely used system to conditionally modify gene expression in mouse models ...

The Cre/loxP-mediated recombination system, a powerful conditional gene expression and gene deletion tool, has been widely used to test the functions of specific gene products in mouse development and ...

The transgenic mice in which Vil1 acts as a promoter of ... Recombination efficiency at different loxP sites and genomic loci can vary. Thus, the findings guide Cre activity in these four Vil1 ...