The transition from preclinical development to clinical trials is a critical, with approximately 89% of drugs failing. Nearly half of these failures stem from unexpected and unmanageable human ...

Genetic engineering technologies allow for the creation of custom-made cells that can have transformative effects on human health. This is best exemplified by chimeric antigen receptor (CAR ...

A multi-institutional team developed a chimeric antigen receptor (CAR ... KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar ...

More information: Russell W. Cochrane et al, High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells, Molecular Therapy - Methods & Clinical ...

From a meeting that celebrates basic research and being "first," a look at 3 data sets on therapies that would break new ...

Researchers have harnessed synthetic biology to engineer chimeric antigen receptor (CAR ... one flank with a tumor expressing human epidermal growth factor receptor 2 (Her2), which CAR T cells ...

If you or a loved one has diffuse large B-cell lymphoma (DLBCL) that is no longer responding to treatment or came back after treatment, chimeric antigen receptor (CAR) T-cell therapy may be an option.

Biotechnology company Eutilex is developing a portfolio of immuno-oncology T cell, chimeric ... receptor CAR T program, for relapsed and refractory hematologic malignancy, targets human leukocyte ...