The transition from preclinical development to clinical trials is a critical, with approximately 89% of drugs failing. Nearly half of these failures stem from unexpected and unmanageable human ...

From a meeting that celebrates basic research and being "first," a look at 3 data sets on therapies that would break new ...

Genetic engineering technologies allow for the creation of custom-made cells that can have transformative effects on human health. This is best exemplified by chimeric antigen receptor (CAR ...

A multi-institutional team developed a chimeric antigen receptor (CAR ... KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar ...

This enables potential use cases in a spectrum of medicinal domains for proof-of-concept research, like engineering T cells for chimeric antigen receptor ... in lymphocytes. Human primary T ...

A specialized model used by researchers is becoming a valuable tool for studying human brain development, diseases and ...

Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and ...

The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain. Science Advances , 2025; 11 (18) DOI: 10.1126/sciadv.adq8089 Cite This Page : ...