A likely candidate for this early pro-apoptotic response is cathepsin B (CTSB) as it is abundant and neutral active, that is, in a time when most lysosomes are still intact (Supplementary Figure S1).

Lysosomes are cellular organelles with a proteolytic function and possess an impressive set of protease enzymes 8 dedicated to the degradation of both intracellular material, such as damaged or ...

Does TMEM175 influence how lysosomes function, too? Indeed, in TMEM175 knockout cells, the lysosomal hydrolase cathepsin B cleaved less fluorogenic substrate. Expression of wild-type TMEM175, but not ...

Given that cancer cell lysosomes often exhibit high levels of the enzyme ‘Cathepsin B,’ responsible for protein degradation, the micelles specifically target these lysosomes. Once inside the ...

Given that cancer cell lysosomes often exhibit high levels of the enzyme 'Cathepsin B,' responsible for protein degradation, the micelles specifically target these lysosomes. Once inside the ...

Further, the scientists discovered that cathepsin-B, a protein that cuts synuclein in the lysosome, needs to be inactive in addition to the presence of long fatty acid chains in order to produce ...

General lysosome inhibitors also blocked processing ... He found the same in vitro: only cathepsin L, but not B or D, could robustly digest progranulin in a test tube. The investigators mapped the ...

That search turned up cathepsin B, a protein best known for its association with cell death and some diseases. Experiments showed that blood levels of cathepsin B rose in mice that spent a lot of ...