"An exciting finding was when we tried to treat the obese mice with colon inflammation by lowering their inflammation, it actually stopped the ERK pathway in the liver from activating," explains Imai.

Deficiency: If you have a vitamin B12 deficiency you will feel tired or weak, pale skin, loss of appetite, infertility and others. It can also cause balance issue, depression and poor memory.

Researchers at the Tohoku University Graduate School of Medicine have uncovered a key primary step in the hepatic ERK pathway ...

Introduction: B-cell receptor (BCR) signaling has revealed itself as a critical pathway in the pathogenesis of B-cell lymphoma. Within this pathway, the inhibition of Bruton's tyrosine kinase (BTK) or ...

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Instead, more cells decided to turn into ectoderm tissue, the type that eventually gives rise to our nervous system. This study shows that glycolysis helps activate key signaling pathways (Wnt ...

In this study, we found that AFC significantly inhibited the growth of five types of colon cancer cells, downregulated the mRNA and protein levels of M2-type pyruvate kinase (PKM2), and reduced ...

diffuse large B-cell lymphoma (DLBCL) not otherwise specified who are ineligible for autologous stem cell transplant (ASCT). With this approval, this Columvi combination is the first bispecific ...

Columvi is a CD20xCD3 T-cell engaging bispecific antibody designed to target CD3 on the surface of T cells and CD20 on the surface of B cells. Columvi was designed with a novel 2:1 structural format.