B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children, accounting for around 85% of pediatric ...

Chimeric antigen receptor (CAR) T cells ... B-cell lymphomas. 1-9 These therapies incorporate either a 4-1BB (CD137) or a CD28 intracellular costimulatory domain to enhance T-cell activation ...

According to Kahlenberg, although B-cell activation is “important for many patients” with lupus, treatment needs to be tailored and individualized. For example, belimumab (Benlysta ...

Boehringer Ingelheim has joined the surge of companies entering the B-cell depletion space ... event in December 2024, CD3 will activate every T cell that it comes into contact with.

For example, some strategies activate a patient’s own NK cells ... In one case, such allogeneic NK cells are engineered with a B cell-targeting/depleting monoclonal antibody (mAb) as a treatment ...

Three doses of COVID-19 mRNA vaccination induce long-lasting antibody and memory B-cell responses ... lower capacity to neutralize the virus and activate other immune functions, had a higher ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Syndecans (SDCs) are ...

In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells ...

A look at cancer cells: Thanks to an innovative method of super-resolution microscopy, researchers observed with molecular resolution in 3D how therapeutic antibodies attack and alter B cells ...

An exhaustive pre-clinical study of a circRNA drug candidate (cmRNA1210) encoding IL-12sc for anti-tumor therapeutics. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This ...

Increased translocation of fatty acid-transporter CD36 from its endosomal storage site to the cell surface is one of the earliest ... disassembly via binding with glycolytic enzymes on activation of ...

This study is the first to demonstrate that IMPDH2 activation and nucleolar hypertrophy are essential for EBV-induced B cell transformation and that IMPDH2 inhibition can suppress PTLD.