Lysosomes play a vital role in maintaining cellular health by clearing debris and supporting processes like autophagy. Lysosome impairment contributes to many diseases, including Alzheimer's ...

Overall Survival Analysis of the Phase III CodeBreaK 300 Study of Sotorasib Plus Panitumumab Versus Investigator's Choice in Chemorefractory KRAS G12C Colorectal Cancer Using the National Cancer ...

Paratek Pharmaceuticals will acquire OptiNose for approximately $300 million, or up to $14 per share. The transaction is expected to close as early as mid-2025. Unlock your all-in-one trading ...

To date, many mitophagy (selective mitochondrial autophagy) receptors have been identified in mammals and other species. While the loss of mitophagy receptors has been shown to impair mitochondrial ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

In order for the degradation of cellular components through autophagy to occur, they must first be recognised as waste. This is done by receptor and other adapter molecules. However, it was ...

Autophagy is a process by which cells break down and recycle their own components to maintain homeostasis. The research team scrutinized the autophagy process in astrocytes and discovered that ...

Autophagy defects have been linked to aging, as well as, with the emergence of age-related disorders, such as diabetes, cardiovascular diseases, cancer and neurodegenerative diseases.

Clinical trial results presented at the 2023 European Society of Medical Oncology (ESMO) annual meeting and at the 2023 San Antonio Breast Cancer Symposium (SABCS) combined with earlier reports from ...

and that autophagy receptor optineurin (OPTN) and an E3-ligase RCHY1 are required for this process. Mutual OPTN and TANK-binding kinase 1 (TBK1) activation is essential for melanophagy. Moreover, ...

Using various molecular biology techniques, the team found that deleting the gene encoding TBK1 prevented association of an autophagy adaptor called optineurin (OPTN) during Parkin-mediated ...