Alternative splicing (AS) is a major contributor to transcriptome and proteome diversity. Evolutionary studies help to address questions that are fundamental to understanding this important process.

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

Alternative splicing has a crucial role in the generation of biological complexity, and its misregulation is often involved in human disease. Here we describe the assembly of a ‘splicing code ...

Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to ...

A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease. Cohesin is known to play a key part in transcription ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

RIVERSIDE, Calif. -- Alternative splicing, a clever way a cell generates many different variations of messenger RNAs — single-stranded RNAs involved in protein synthesis — and proteins from ...

It turns out that one type of abnormality that often pops up in metastatic tumor cells affects a process known as alternative splicing. Alternative splicing determines which protein will be produced ...

A study published Wednesday (March 1) in Science Advances suggests that cohesin regulates alternative splicing—the phenomenon when coding regions of a gene are combined in different ways during ...

Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person's risk of alcohol use disorder (AUD).

An important process that modifies RNA sequences is alternative splicing, whereby specific sequences within the RNA molecule may be rearranged, included or excluded. This process results in ...