For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

imageimageIn this study miR-33a/b were identified as negative regulators of skeletal muscle regeneration by targeting Cdk6, Fst, and Abca1. Inhibition of miR-33a/b can be a promising strategy for the ...

Pathogenic genetic variants in the NuRD component CHD3 cause Snijders Blok–Campeau Syndrome, a neurodevelopmental disorder manifesting with intellectual disability and craniofacial anomalies. To ...

The primary cilium plays a crucial role in regulating whole-body energy metabolism, as reflected in Bardet-Biedl syndrome (BBS), where ciliary dysfunction leads to obesity due to hyperphagia and white ...

imageimageThis study reveals the necessity of biallelic functional Kif11 for bipolar spindle assembly in acentrosomal oocytes and a spatially differential requirement for homologous chromosome ...

Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown.

ADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that during proteotoxic stress, cellular ADP-ribosylation increases, ...

imageimageThe basis and significance of SUMO1 vs SUMO2/3 conjugation preference remains incompletely understood. Here, deacetylation of SAE2, the SUMO-activating E1 enzyme, during mitosis is found to ...

imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins ...