Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level ...

Sarika Kondra and her co-author's TSR-based method represents a major advancement in protein structure analysis, integrating ...

This valuable study presents an analysis of evolutionary conservation in intrinsically disordered regions, identified as key drivers of phase separation, leveraging a protein language model. The ...

Yet, despite more than 20 years of study, the sweet receptor’s precise architecture remained elusive, even as scientists ...

Perform pairwise secondary structural alignments of proteins using the US-align (TM-align) algorithm and generate an accompanying dendrogram to visualise the structural relationship between them.

Molecular biology has transitioned to a new era where precise genetic manipulation plays a critical role in research, medicine, and biotechnology. Among the vital tools in this field are cloning ...

The amount of protein you need depends on many factors, including activity level, age, muscle mass, and overall health. Protein is one of three essential macronutrients, alongside carbohydrates ...

Integral membrane protein structure determination traditionally requires extraction ... After a best model was achieved, the particles were further sorted by a 3D classification without alignment ...

Credit: Photo realized Courtesy of DIFFERENT- Restaurant in the Darkness. Source IPC PAS, Grzegorz Krzyzewski Researchers have uncovered the 3D structure of RBP3, a key protein in vision, revealing ...

Multiple sequence and structure alignment with top benchmark scores scalable to thousands of sequences. Generates replicate alignments, enabling assessment of downstream analyses such as trees and ...

State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China ...