Toward experiment-guided AlphaFold: Researchers overcome AI tool's single-conformation limitation

The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and ...
eLife

TopoMetry systematically learns and evaluates the latent geometry of single-cell data

A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and ...