News

C&EN5d
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon ...
bjo.bmj6d
Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
The cells stained positive for CK14 and ABCG2. Conclusions: A novel anatomical structure has been identified at the human limbus, which demonstrates characteristics of being a stem cell niche. The ...
C&EN7d
Role of Mechanical Factors in Controlling the Structure–Function Relationship of PFSA Ionomers
Thus, there exists a balance between the chemical and mechanical energies which controls the structure–function relationship of the ionomer. In this paper, it is reported how and why thermal ...
Nature9d
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
which explains how a set of intracellular and extracellular forces controls the cell structure. Cells are complex structures, the shape of which can be adequately explained using the concept of ...
C&EN9d
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization
‡ Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China § CAS Key Laboratory of ...
C&EN10d
In Operando Detection of the Onset and Mapping of Lithium Plating Regimes during Fast Charging of Lithium-Ion Batteries
School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States ...
C&EN15d
Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties
Molecular Signaling and Cell Death unit, VIB Inflammation Research Center, 9052 Ghent, Belgium Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF ...
eLife20d
Shining light on the dark matter of pertussis: evidence for an asymptomatic carriage state from a longitudinal cohort of mother/infant dyads
This important study provides evidence for asymptomatic Bordetella pertussis carriage among mothers in a longitudinal cohort in Zambia, significantly advancing understanding of transmission dynamics.
C&EN21d
Synthesis and Structure–Activity Analysis of Icaritin Derivatives as Potential Tumor Growth Inhibitors of Hepatocellular Carcinoma Cells
Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, ...
GEN22d
Illumina Sues Element Biosciences, Alleging Infringement of Flow Cell, Imaging Patents
and cell structure within single cells. This year Element is rolling out upgrades or “Innovation Roadmap” for AVITI24, with the company expecting during the second half of 2025 to introduce to ...
Nature22d
Structure, expression, and developmental function of early divergent forms of metalloproteinases in Hydra
As a member of the Phylum, Cnidaria, hydra arose early during metazoan evolution before divergence of the protosome and deuterostome branches. Its body plan is organized as a gastric tube with a ...