When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are ...

A new study in Small introduces a modular protein-DNA platform using covalent, site-specific links to create programmable ...

Can a small fish help identify possible treatments for an ultra-rare inherited disease found in an Alabama boy? The genetic ...

XMEA is a recessive, genetic disease that causes progressive muscle weakness. Can a small fish help identify possible ...

A paper titled "Functional implications of unusual NOS and SONOS covalent linkages found in proteins," by Matthew D. Lloyd, ...

EPGF is a test-time computation framwork, which ensures that generated protein sequences are not only statistically coherent but also biologically viable, addressing a critical limitation in current ...

Abstract: The order of amino acids in a protein sequence enables the protein to acquire a conformation suitable for performing functions, thereby motivating the need to analyze these sequences for ...

† Department of Structural Biology, St. Jude Children’s Research Hospital, 263 Danny Thomas Place, Memphis, Tennessee 38105, United States ‡ Department of Biomedical Engineering and Center for ...

Template-based protein design relies on using existing protein structures as starting points to guide the design process - for both sequence and backbone redesign. Since protein structure determines ...

However, sequence-based analyses of metagenomes should be complemented ... Using this protocol, libraries of protein domains can be quickly generated, from the DNA of any intron-less genome, such as ...

(1) While the authors substituted the ACG near-cognate initiation codon with other near ... the expression levels of FMRpolyG proteins upon knockdown of these molecules in disease model cells ...