One ring to bind them all Using state-of-the-art cryo-electron microscopy, the research team was able to decipher the structure.To do this, the membrane proteins were shock-frozen in a solution ...

AfCycDesign: Cyclic offset to the relative positional encoding in AlphaFold2 enables accurate structure prediction ... transition metal binding sites in proteins. It integrates geometric and ...

An enzyme as key to protein quality Date: May 9, 2025 Source: University of Würzburg Summary: In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's ...

When Alphabet announced in 2021 that its AlphaFold AI could predict the structure of almost every known protein, it was a major story, not just in the pharma world, but beyond. Yet, that was far ...

Protein 4.1R in red blood cells has multiple binding sites for membrane and skeletal proteins and plays a critical role in maintaining cell morphology and membrane mechanical properties 1. The ...

The Protein Structure Initiative of the US National Institutes of Health has entered its second year. Its status is reported here, as discussed at December's meeting of the principal investigators.

Motor protein structure describes the structure of molecular motors capable of moving along a cytoskeletal filament. In many cases, motor proteins transport cargo in a particular direction along ...

we describe the 1.9 Å resolution structure of E. coli FhuD in complex with gallichrome. FhuD adopts a novel fold and represents a new class of iron binding ABC-type transport proteins.