The special picrosirius red staining highlights the natural birefringence of collagen fibers when exposed to polarized light. The results from birefringence allow to evaluate the organization of the ...

Paraffin-embedded LV tissue sections (4 μm) were stained with picrosirius red to determine interstitial fibrosis using Aperio ScanScope Console v.8.0.0.1058 (AperioTechnologies, Inc). Picrosirius red ...

Histological sections 5-μm thick were obtained from each sample and stained using the following histochemical techniques: hematoxylin and eosin to evaluate tissue integrity; Picrosirius red without ...

Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF) and is characterized by skeletal muscle (SkM) dysfunction with impaired oxidative capacity. To maintain ...