Leptin-deficient (ob/ob) mice are obese and infertile. Dysfunctions of the ovaries are preferentially related to leptin-deficiency. Ovaries were obtained from three-month-old mice either ...

Eight-week-old female ob/ob mice received daily intraperitoneal injections of vehicle (six mice), 0.2 μg of nonmutant leptin per gram of body weight (six mice), or 0.2 μg of D100Y leptin per ...

However, RYGB failed to generate the same effects in leptin-deficient ob/ob mice, which suffered a weight regain over the pre-surgery level. In ob/ob mice, body weight was reduced by RYGB ...

To test this, the researchers used two types of obese mice: ob/ob mice, which are susceptible to putting on abdominal fat, and db/db mice, which put on fat all over. Leptin signaling, which ...

They also conducted similar experiments on ob/ob mice that were genetically programmed to exhibit leptin dysfunction. Leptin - a hormone synthesized by fat cells - controls satiety and energy ...

Researchers in Japan have crossed an AD mouse (APP23) with two types of diabetic cousins, the leptin-deficient obese mouse (ob/ob) and the spontaneously diabetic NSY mouse. As senior author Ryuichi ...