Methods: Study 1: ob/ob mice (Ob-CT) were treated with either prebiotic (Ob-Pre) or non-prebiotic carbohydrates as control (Ob-Cell). Study 2: Ob-CT and Ob-Pre mice were treated with GLP-2 antagonist ...

Specifically, AgRP neurons, which are located in the hypothalamic arcuate nucleus (ARC) and are hyperactive in Lep ob/ob mice and other rodent models of T2D. To investigate whether chronic AgRP neuron ...

We used multiomic data collected from the plasma and livers of wild-type and leptin-deficient obese (ob/ob) mice at multiple time points during starvation to construct a starvation-responsive ...

Edited by: Stephen P. Hoffert D.S. Weigle, T.R. Buchowski, D.C. Foster, S. Holderman, J.M. Kramer, G. Lasser, C.E. Lofton-Day, D.E. Prunkard, C. Raymond, J.L. Kuijper ...

Leptin deficient ob/ob mice are commonly used to study the effects of obesity and insulin resistance on myocardial substrate metabolism. However, it is difficult to discern the specific contribution ...

cLaboratory of Protein and Peptide Pharmaceuticals, Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China dInstitute of Systems Biomedicine, School of ...

Starting with obesity, mice deficient in leptin (Ob/ob mice) or with non-functioning leptin receptors (db/db mice) are commonly used to model obesity, resulting in severe steatosis, a hallmark of ...

Here, we examine the effects of this exercise mimetic in mouse models of obesity and metabolic syndrome. Diet-induced obese or ob/ob mice were administered SLU-PP-332 and the effects on a range of ...

Conversely, BHLHE40 deficiency in hypoxic MIN6 cells or β‐cells of ob/ob mice reverses defects in insulin secretion. Mechanistically, BHLHE40 represses the expression of Mafa, encoding the ...

They also conducted similar experiments on ob/ob mice that were genetically programmed to exhibit leptin dysfunction. Leptin - a hormone synthesized by fat cells - controls satiety and energy ...