For example, mice lacking PGC1α have diminished content and activity of mitochondrial energy-metabolic proteins, resulting in mildly impaired contractile function in ex vivo beating ...

Methods: Study 1: ob/ob mice (Ob-CT) were treated with either prebiotic (Ob-Pre) or non-prebiotic carbohydrates as control (Ob-Cell). Study 2: Ob-CT and Ob-Pre mice were treated with GLP-2 antagonist ...

Specifically, AgRP neurons, which are located in the hypothalamic arcuate nucleus (ARC) and are hyperactive in Lep ob/ob mice and other rodent models of T2D. To investigate whether chronic AgRP neuron ...

Larger animal models allow translational research with catheterization of aorta and coronaries, which is a clear advantage compared with small animals such as mice that are usually too small for ...