Samples were obtained from C57Bl/6 mice aged 16 weeks. We studied the ob/ob genetically obese mouse model and diet-induced obesity model. We extended our results in mice to a cohort of morbidly ...

Halofuginone shows promise for weight loss by boosting key metabolic regulators. Overweight and obesity have quickly become ...

In recent years, overweight and obesity have become a serious global health problem, posing significant risk factors for ...

We show that hepatic lipid content is similar in ob/ob and ob/ob–p55/p75-null mice (Table 1). Moreover, serum transaminase levels are also not significantly different between ob/ob mice with or ...

Halofuginone can regulate appetite and energy metabolism by increasing the levels of growth differentiation factor 15 (GDF15) ...

Specifically, AgRP neurons, which are located in the hypothalamic arcuate nucleus (ARC) and are hyperactive in Lep ob/ob mice and other rodent models of T2D. To investigate whether chronic AgRP neuron ...