Leptin-deficient (ob/ob) mice are obese and infertile. Dysfunctions of the ovaries are preferentially related to leptin-deficiency. Ovaries were obtained from three-month-old mice either ...

However, RYGB failed to generate the same effects in leptin-deficient ob/ob mice, which suffered a weight regain over the pre-surgery level. In ob/ob mice, body weight was reduced by RYGB ...

Eight-week-old female ob/ob mice received daily intraperitoneal injections of vehicle (six mice), 0.2 μg of nonmutant leptin per gram of body weight (six mice), or 0.2 μg of D100Y leptin per ...

To test this, the researchers used two types of obese mice: ob/ob mice, which are susceptible to putting on abdominal fat, and db/db mice, which put on fat all over. Leptin signaling, which ...

Researchers in Japan have crossed an AD mouse (APP23) with two types of diabetic cousins, the leptin-deficient obese mouse (ob/ob) and the spontaneously diabetic NSY mouse. As senior author Ryuichi ...

Share on Pinterest A recent study finds that a failed cancer drug reduces appetite and boosts weight loss in mice. lingqi xie/Getty Images Small doses of a drug once considered for treating tumors ...

In that study, the researchers used the 3D data to identify changes in the Islets of Langerhans in the obese (ob/ob) mice. This animal model is often used to study initial metabolic changes that ...