The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

have shown how it operates like the lock on a canal to transport pyruvate, a molecule generated in the body from the breakdown of sugars, into mitochondria. The MPC was first proposed to exist in ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria ... to pyruvate. To transport pyruvate into the mitochondrion, first an outer ...

Mitochondria, often called the "powerhouses" of the cell, are responsible for converting nutrients into usable energy that ... can decline significantly. As NADH levels drop and oxidative stress ...

breaking it up to liberate the mitochondria, separating them from other cellular gubbins in a centrifuge and perfusing them back into the failing heart. There is a chance that Dr McCully’s ...

"Until a few years ago, we were sure that mitochondria ... I of the electron transport chain. Complex I transfers electrons (initially derived from food) from the coenzyme NADH (nicotinamide ...

Glycolysis (in the cell’s cytoplasm), where glucose is broken down into pyruvate, NADH and 2 ATP; The Krebs cycle (in the mitochondria), where pyruvate is further processed to produce NADH and FADH 2, ...

Mitochondrial oxidative ... either it is converted into lactate (LAC) that leaves the cell, or it enters the mitochondrion (yellow) to form Acetyl coenzyme A (AcCoA). The latter is processed by the ...

Loss of a cytoplasmic short form of SIRT3 (sirtuin 3) in diabetic heart leads to increased AGO2 malonylation, which is responsible for compromised AGO2 transport into mitochondria by ... the ...

Inside cells, chemical reactions turn food into energy. These reactions often ... NADH then carries electrons (two electrons per NADH molecule) to the electron transport chain in the mitochondria of ...