Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

Vesicles are small blisters that can appear on your skin. They can be a symptom of a medical issue or a sign of tissue injury. Some conditions, like contact dermatitis or cold sores, may not ...

Notably, highly metastatic triple negative breast cancer cells, that are better adapted at balancing elevated proliferation with invasive capacity also exhibit a dependency on lysosomes and ...

these proteins are trafficked out of the cell rather than into lysosomes when there is no COMMD3. Similarly, extracellular vesicles from iPSC-derived neurons lacking COMMD3 contained 12 times as much ...

Liver Surgery and NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, ...

The School of Pharmacy, Fujian Medical University, Fuzhou 350122, Fujian, P. R. China Innovative Drug Research Institute, Fujian Medical University, Fuzhou 350122, Fujian, P. R. China Fujian Key ...

The proteins are clustered in one vesicle and then another vesicle and then finally handed off to the lysosome. We think NU-9 targets something in the early stage of that relay, but we don't know ...

The proteins are clustered in one vesicle and then another vesicle and then finally handed off to the lysosome. We think NU-9 targets something in the early stage of that relay, but we don’t ...

Primary seminal vesicle tumors are very rare; less than 100 cases have been reported in the English literature to date. Patients usually present with lower urinary tract symptoms or hematospermia.