were the first to suggest that these particular vesicles were pre-lysosomes (Smith & Farquhar 1966). Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore.

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

elegans, ATG-9 vesicles selectively accumulate around mildly damaged lysosomes. Notably, reducing the phospholipid scramblase activity of ATG-9 significantly enhanced the repair of mildly damaged ...

This "transmembrane" region is known to house a channel that helps membranous vesicles, such as lysosomes, regulate pH—a measure of acidity or alkalinity—by transporting pH-lowering protons ...

We found that Rab7, a protein present on the MVB’s outer membrane, is a regulator involved in dictating the fate of the vesicles. We believe that active Rab7 directs the EV toward the lysosomes, but ...

Questions to consider: How is vesicle formation and transport included in the model ... bound organelles Endosome transport from the Golgi or Plasma Membrane to the Lysosome Using animated or active ...

According to biology textbooks, a macrophage engulfs a bacterium, internalizes it in a toxin-filled vesicle called a phagosome, then shuttles the cellular remains to a lysosome for degradation. But ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

these proteins are trafficked out of the cell rather than into lysosomes when there is no COMMD3. Similarly, extracellular vesicles from iPSC-derived neurons lacking COMMD3 contained 12 times as much ...