A genetic mutation that fuses two genes drives several different cancer types by forming networks of protein interactions that alter gene expression in cells, a study by UT Southwestern Medical Center ...

This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Oligonucleotides work as short strands of synthetic DNA or RNA that can reduce, restore or modulate RNA through several different mechanisms.

Despite that, the first RNA-targeting therapeutic in the market was launched only five years ago, and the vast majority of all Food and Drug Administration–approved drugs target proteins.

When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...

This study is significant in that it newly identified the regulation of RNA editing within astrocytes as a key mechanism behind neuroinflammatory responses. In particular, it suggests that ADAR1 ...

This revolution is being powered by RNA technology — and Canada is uniquely positioned to lead it. While the swift development of COVID-19 vaccines appeared to be a sudden scientific triumph ...

3 Identifying disease-specific RNA signatures within exosomes allows researchers to gain useful insights into disease mechanisms, leading to the development of novel therapeutic strategies.

The researchers tested the RNA origami in a lipid vesicle, a simple cell model system widely used in biology. Using so-called RNA aptamers, the artificial cytoskeleton was bound to the cell membranes.

Potentially safer and more flexible than DNA editing, RNA editing has made important strides during the last decade. In 2024, the field inched further forward, with Wave Life Sciences announcing the ...

Concerted efforts to deepen understanding of RNA modifications and their role in living systems hold the potential to advance human health, improve crop yields, and address other pressing societal ...