Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, ...

A genetic mutation that fuses two genes drives several different cancer types by forming networks of protein interactions that alter gene expression in cells, a study by UT Southwestern Medical Center ...

This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, ...

This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption ... at 0.5 million for transfection using Lipofectamine 2000 ...

The present study aimed to explore the dysfunctional mechanism of cellular senescence in AD by joint analysis of single-cell RNA (scRNA) and bulk sequencing data to identify the key transcription ...

In this work, we examined the delivery efficiencies and immunological impacts of two representative NANPs─DNA cubes and RNA cubes─complexed with a benchmark delivery vehicle, Lipofectamine 2000 vs.

Oligonucleotides work as short strands of synthetic DNA or RNA that can reduce, restore or modulate RNA through several different mechanisms.

Using integrated genomic analyses, we characterized extensive NRF2-dependent enhancer RNA (eRNA) synthesis and NRF2-mediated ... These findings detail mechanisms of NRF2-dependent transcriptional ...