Variants are selected by conducting stepwise likelihood ratio tests. The superiority of the proposed method over two existing variant selection methods is demonstrated in a simulation study.

A confidence interval on a parameter can be constructed by inverting a Wald-based or a likelihood ratio-based test. The approximate % Wald confidence interval for a parameter is ...

Specifically: Shin palpation test OR 4.63, 95% CI 2.5 to 8.5, Positive Likelihood Ratio 3.38, Negative Likelihood Ratio 0.732, Pearson χ2 p<0.001; Shin oedema test OR 76.1 95% CI 9.6 to 602.7, ...