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Cell's protein cleanup fails when crucial enzyme is blocked, study finds
In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly ...
eLife4d
Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers
In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...
Frontiers1d
Endolysosomal and autophagy dysfunction in neurodegenerative diseases
Manuscript Summary Submission Deadline 5 August 2025 | Manuscript Submission Deadline 23 November 2025 ...
eLife2d
Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction pathways and genes induced in response to lysosomal ...
Frontiers5d
The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy
We also spotlight the effects of intestinal flora and its metabolites, enterocyte-derived exosomes, cholinergic anti-inflammatory pathway, peripheral T cells and their cytokines on septic ...
Medscape2d
Anaplasma Phagocytophilum
Future Microbiol. 2012;7(6):719-731.