School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, ...

Though the exact etiology remains unclear, genetic factors, particularly mutations in ion channels and neurotransmitter receptors, play a crucial role in its pathogenesis. The condition is marked by ...

This patent highlight describes a series of novel 2-pyrrolidone derivatives that act as negative allosteric modulators (NAMs) of GluN2B-containing N-methyl-d-aspartic acid receptors (NMDARs). These ...

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand ...