If there is strong evidence for the diagnosis of gout, then urate crystal deposition needs to be established (by synovial fluid analysis and compensated polarized light microscopy, or, by use of ...

The finding of intracellular, negatively birefringent, needle-shaped crystals on polarized light microscopy confirms a diagnosis of gout. Colchicine or nonsteroidal antiinflammatory drugs (NSAIDs ...

In gout, urate crystals ... Since urate crystals precipitate within the affected joint, their presence is viewable under polarized light microscopy of synovial fluid. 17 If observed, this is ...

Liquid crystals ... The microscope combines polarized fluorescence technology, a valuable tool for measuring the orientation of molecules, with a dual-view light sheet microscope (diSPIM), which ...