A systematic survey of archived protein structures has revealed dozens of examples of a previously overlooked covalent ...

A new research perspective was published in Aging, titled "Trioxidized cysteine and aging ... including those involving cysteine (Cys) residues in aging proteomes. Specifically, the formation ...

characterized by an imbalance between oxidants and antioxidants - leads to the formation of oxidative posttranslational modifications (PTMs), including those involving cysteine (Cys) residues in ...

Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of cysteine residues in GSDMD oligomerization. We show that GSDMD preassembles at the ...

This redox reaction takes place at cysteine residues situated at key structural and functional sites within the catalytic domain (the part of the protein that causes the enzymatic reaction). In ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known ...

The role of alpha-1 antitrypsin (AAT) on lipopolysaccharide (LPS)-induced release of interleukin 1β (IL-1β) from human peripheral blood mononuclear cells (PBMCs) requires a free cysteine residue at ...

This amino acid residue is nearly three times as abundant as cysteine in the body: an average of 32 lysines dot every protein. There is tremendous utility in being able to expand the covalent ...

The intramolecular linkage is an N-O-S bridge formed by oxidizing the amine side group of a lysine and the thiol of a cysteine residue. The team that made the discovery, led by Kai Tittmann at the ...