Scientists have engineered a monoclonal antibody that can protect mice from a lethal dose of influenza A, a new study shows.

The transition from preclinical development to clinical trials is a critical, with approximately 89% of drugs failing. Nearly half of these failures stem from unexpected and unmanageable human ...

From a meeting that celebrates basic research and being "first," a look at 3 data sets on therapies that would break new ...

If you or a loved one has diffuse large B-cell lymphoma (DLBCL) that is no longer responding to treatment or came back after treatment, chimeric antigen receptor (CAR) T-cell therapy may be an option.

Adoptive T cell therapy has evolved with innovations such as chimeric antigen receptor (CAR)- and engineered T cell receptor (TCR)-T cell therapies that target tumor surface antigens or ...

We demonstrate glucocorticoid signalling is essential for normal cilia formation in mouse and human renal tubules. RNA sequencing of E18.5 kidneys from glucocorticoid receptor (GR) null mice ...

Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new ...

The presentation was titled “A Phase 1, Open-label, Single Center Study of an Autologous Fully humanized Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy in Subjects with Non ...

A multi-institutional team developed a chimeric antigen receptor (CAR ... KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar ...

While there are notable differences between mouse and human brains, many organizational principles remain conserved across species. The research focused upon a part of this region called the primary ...