The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells’ major recycling centers, and on an enzyme called cathepsin B. In Alzheimer’s disease, this ...

JAMA study confirms that vaccines measurably alter menstrual cycle timing, offering direct evidence of neuroendocrine effects ...

As expected, PDNPs showed a satisfactory biocompatibility profile; further experiments indicated that the nanoparticles were predominantly localized within lysosomes ... solution of the lysosomal ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for ...

The cast of the iconic 1980's film "The Breakfast Club" – Molly Ringwald, Ally Sheedy, Judd Nelson, Anthony Michael Hall and Emilio Estevez – reunited for the first time in 40 years during a ...

The entire cast of 1985’s The Breakfast Club reunited on the same stage for the first time in 40 years. “I skipped all my high school reunions, so this was something that finally felt like I ...

The cast of “The Breakfast Club” reunited over the weekend for the first time in 40 years. Stars of the 1980s coming-of-age movie took to the stage at the Chicago Comic and Entertainment Expo ...