An "armored" CAR T cell therapy engineered to secrete interleukin-18 (IL 18) demonstrated cancer reduction in 81% and complete remission in 52% of patients with treatment-resistant B-cell lymphomas.

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept ...

State officials and AstraZeneca marked the opening Monday of a cell therapy facility in Rockville that aims to create pathways to jobs for the state’s STEM professionals. AstraZeneca completed a ...

A French research team from Institut Curie, the CNRS and Inserm has just developed a new class of small molecules that bring about the destruction of cell membranes, and hence triggers cell death ...

In an aging brain, cells that stop working yet refuse to die may play a role in dementia—making them key targets for future medicines. Senescent cells—also called zombie cells (background ...

As it applies to the development of cell therapies, AstraZeneca’s chief of global operations, Pam Cheng, admits that the company is a “little late to join the party.” But just because AZ has ...

The facility, which was previously used by Novartis to manufacture the gene therapy Zolgensma, was picked up by BMS in early 2023 to bolster viral vector capacity for its commercial cell therapy ...

Proton transport is crucial for many life processes, such as how cells produce energy. Until now, it was widely believed that protons move mainly by hopping between water molecules and amino acids.

Cell phones and depression Source: Mart Production/Pexels The Mood-Phone Connection Research consistently demonstrates associations between problematic smartphone use and negative mood states.