A review led by Academician Yulong Yin from the Institute of Subtropical Agriculture of the Chinese Academy of Sciences has ...

The expression of E50K OPTN led to defective autophagy and RGC cell death. It also increased ROS levels through an unknown mechanism. Notably, antioxidant treatment prevented RGC death, indicating ...

In these models, mHTT is detected in autophagic vacuoles and colocalizes with autophagy receptors p62/SQSTM1 and ubiquitin. Although ALP alterations in the Q175 model are milder and later onset ...

Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D (CTSD ...

The study also found that when autophagy was blocked, certain glutamate receptors (which affect how brain cells communicate) built up in the lateral habenula. When autophagy was restored ...

Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged to treat IgG-mediated autoimmune disease. 4,5 Here, we review ...

Get Instant Summarized Text (Gist) A 2016 bird flu variant was found to be one mutation away from binding to human receptors, highlighting the potential for avian influenza to adapt to humans. The ...

By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions with autophagy, a key degradation pathway ... PKA activity has not been linked to specific G-protein coupled receptors ...

Optinose, Inc. (NASDAQ: OPTN)’s sale to Paratek Pharmaceuticals. Under the terms of the proposed transaction, Paratek will acquire Optinose for $9.00 per share in cash, plus up to $5.00 per ...