Research that focused on blocking the renin-angiotensin system (RAS ... In addition to inhibiting the conversion of AT-I to AT-II, ACE inhibitors block the degradation of bradykinin via kininase ...

Angiotensin II doesn’t just affect blood pressure—it also plays a role in brain function, potentially influencing mood and ...

The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

This medication is an angiotensin II receptor antagonist, prescribed for high blood pressure. This medication is an angiotensin II receptor blocker (ARB), prescribed for high blood pressure either ...

Renin converts angiotensinogen into angiotensin I, which ACE then converts into angiotensin II, a vasoconstrictor. ACE inhibitors and ARBs lower blood pressure by acting on different steps of this ...

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Angiotensin I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Angiotensin II David W. Cushman In 1967, John Vane, a consultant at The Squibb Institute for Medical Research ...

Beijing Tide Pharmaceutical Co., Ltd., a subsidiary of Sino Biopharmaceutical Limited (1177.HK), has achieved a milestone in developing its first-in-class analgesic drug (research code: TRD205), a ...

This enzyme converts angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction, increasing afterload, and thus increasing systemic blood pressure. Angiotensin contributes to the ...

Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...