Research that focused on blocking the renin-angiotensin system (RAS ... In addition to inhibiting the conversion of AT-I to AT-II, ACE inhibitors block the degradation of bradykinin via kininase ...

Angiotensin II doesn’t just affect blood pressure—it also plays a role in brain function, potentially influencing mood and ...

This randomised, placebo-controlled, double-blind, multi-centre trial is assessing the safety and efficacy of the therapy in subjects on a stable dose of an angiotensin II receptor blocker (ARB). They ...

The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

Renin converts angiotensinogen into angiotensin I, which ACE then converts into angiotensin II, a vasoconstrictor. ACE inhibitors and ARBs lower blood pressure by acting on different steps of this ...

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu Angiotensin I Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Angiotensin II David W. Cushman In 1967, John Vane, a consultant at The Squibb Institute for Medical Research ...

This medication is an angiotensin II receptor antagonist, prescribed for high blood pressure. This medication is an angiotensin II receptor blocker (ARB), prescribed for high blood pressure either ...

This enzyme converts angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction, increasing afterload, and thus increasing systemic blood pressure. Angiotensin contributes to the ...

Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...