Lorundrostat, a selective aldosterone synthase inhibitor, significantly reduced 24-hour systolic blood pressure in individuals with uncontrolled and treatment-resistant hypertension, according to ...

Medically reviewed by Rafle Fernandez, MD Many medications can help lower high blood pressure (hypertension), but no single ...

Daily treatment with a mineralocorticoid receptor antagonist flopped for reducing serious cardiac events in kidney failure ...

Taking multiple blood pressure medications but still have high readings? Aldosterone excess might be sabotaging your ...

DelveInsight's Chronic Kidney Disease pipeline report depicts a robust space with 75+ active players working to develop 80+ ...

Song, Z. and Zhong, W. (2025) Research Advances in Subtype Classification and Diagnosis of Primary Aldosteronism. Journal of Biosciences and Medicines, 13, 1-11. doi: 10.4236/jbm.2025.136001 .

Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has synthesized cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the ...

Mineralys Therapeutics, Inc.'s lorundrostat shows promise for treating aldosterone-driven hypertension with FDA approval by ...

Most people assume that when blood pressure stays high despite medication, it’s due to stress or an incorrect dose. But resistant hypertension is a specific clinical condition. It means one’s blood ...

A novel treatment, an aldosterone synthase inhibitor, safely and consistently lowered blood pressure in individuals with ...

A new medication called lorundrostat has shown strong potential as a treatment for people with uncontrolled or resistant high ...

2 Moreover, the hazard ratio (1.34) for heart failure hospitalization and for atrial fibrillation (1.37) raised with renin suppression and higher plasma aldosterone levels, respectively. See related ...